Our division is committed to excellence in patient care, teaching, and basic research. The results will help researchers design better immunotherapies against cancer. After analyzing the complex metabolism of these tumors, Brian Van Tine, Jason Held, and co-workers discovered that adding a glutamine inhibitor to an arginine-depleting drug killed the cells and caused tumor regression in mice. WU Record 10/31/18, A large genomic analysis led by Obi Griffith in the Division of Oncology and The McDonnell Genome Institute has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer. Their findings are reported in six papers published April 5 in the journals Cell, Cell Reports and Cell Systems. The Section of Molecular Oncology was developed in close collaboration with the Department of Cell Biology and Physiology. Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 4th Edition, provides quick access to the essential information needed to evaluate a patient on a subspecialty consult service. Kornfeld's research has been instrumental in understanding the workings of lysosomal proteins, which must make their way to the cells' lysosomes in order to digest cellular parts and molecules that are no longer needed and help cells dispose of viruses and bacteria. Located across the street from Harborview Medical Center, the Harborview Hematology/Oncology Clinic consults, evaluates and cares for patients with blood disorders, bleeding problems, hematologic cancer and solid tumors. In 1994, BMT faculty performed approximately 30 transplants. Govindan was honored for his innovative research, including in genomics, aimed at developing better lung cancer therapies and improving patient outcomes. In 2010, these physicians saw 4,000 new patients at three Siteman Cancer Center outpatient locations, including the Center for Advanced Medicine, Barnes West County, and Barnes St. Peters offices. Division of Medical Oncology, Department of Mecicine, University of Washington . Robert Barczewski, MBA, CMPE, after working for fourteen years in the Department of Medicine Business Office, was picked to be the first Administrator of the two divisions. In 1999, after the appointment of Kenneth Polonsky, MD, as the new Chairman of Medicine, Dr. DiPersio was named Chief, Division of Oncology, which consolidated the Divisions of BMT and Medical Oncology into one division. They used computer modeling to accurately predict 75% of effective neoantigens and eliminate 98% of ineffective mutant proteins in melanoma and a common type of lung cancer. Affiliate Professor of Hematology University of Washington School of Medicine Professor for Translational Development of Cellular Therapeutics (GMP), Institute for Transfusion Medicine and Immunotherapy ... Inpatient Oncology Program, University of Washington. Recruitment and research activities are coordinated across the Departments. It was the vision of the late Dr. Stanley Korsmeyer (June 8, 1951 - March 31, 2005) who sought to expand both clinical and translational programs in hematologic and solid tumor malignancies at Washington University School of Medicine. We are particularly proud that many of these trainees and junior faculty have developed international reputations during their time in the Division of Oncology and have assumed major leadership roles at other institutions, including: We have continued to train and recruit the best and the brightest who will play major roles as thought leaders in cancer care and cancer biology either here or at other outstanding Cancer Centers around the country. This edition offers state-of-the-art content, including coverage of new anti-cancer drugs and new biomarkers and therapeutic targets. Many members of this section are national leaders and leading researchers in their areas of expertise. WU Record 10/18/17 | Center for Gene & Cellular Immunotherapy, Seeking new treatments for metastatic breast cancer, Kathy Weilbaecher and colleagues have designed nanoparticles that carry chemotherapy and are targeted directly to tumors that have spread to bone. Among the trial participants, Jian Campian in the Division of Oncology recruited one of the largest groups of patients. The work will be carried out by a research team of physicians and scientists at the Alvin J. Siteman Cancer Center and Washington University School of Medicine with broad expertise in multiple myeloma, genomics, immunology and immunotherapy, imaging and pharmacogenomics. Of the 1,200 new patients placed on therapeutic clinical trials in the past year in the Siteman Cancer Center, the Oncology Division was responsible for over 1,050 accruals. BMT’s clinical research program has also been extremely successful, currently offering patients over 40 clinical trials, accruing over 260 patients to therapeutic clinical trials in 2010. These advances include novel therapeutics and clinical interventions in both solid tumor and hematologic malignancies as well as understanding the genetics and genomics of cancer cells. Find information about and book an appointment with Dr. Jonathan J. Cohen, MD in Miami, FL. The Hematology-Oncology Fellowship Program was overseen and built over the years by Drs. Over the next three years there was significant growth of clinical care and clinical and translational research programs in both divisions. Leukemia 2018 Apr 2 | WU Record 4/24/18, Researchers nationwide have reached a major milestone in describing the genetic landscape of cancer. The grant will fund a clinical trial of the HER2 inhibitor neratinib in combination with fulvestrant in patients with metastatic breast tumors that have HER2 mutations and are estrogen-receptor positive. His studies have laid the groundwork for precision medicine in cancer, which targets treatment to a patient based on the genetic makeup of a tumor and how it responds to therapy. Leuk Lymphoma 2020 Nov 2:1-3; [Epub ahead of print], A Personalized Prediction Model for Outcomes After Allogeneic Hematopoietic Cell Transplant in Patients With Myelodysplastic Syndromes, Biol Blood Marrow Transplant 2020 Nov;26(11):2139-2146, Geriatric Assessment and Quality of Life Changes in Older Adults With Newly Diagnosed Multiple Myeloma Undergoing Treatment, The Characteristics, Treatment Patterns, and Outcomes of Older Adults Aged 80 and Over With Multiple Myeloma, Cancer Therapy Shapes the Fitness Landscape of Clonal Hematopoiesis, Selective Targeting of Alpha4beta1 Integrin Attenuates Murine Graft Versus Host Disease, Epithelioid and Spindle Cell Rhabdomyosarcoma With FUS-TFCP2 or EWSR1-TFCP2 Fusion: Report of Two Cases, Brentuximab Vedotin Plus Nivolumab as First-Line Therapy in Older or Chemotherapy-Ineligible Patients With Hodgkin Lymphoma (ACCRU): A Multicentre, Single-Arm, Phase 2 Trial, A Clickable Probe for Versatile Characterization of S-Nitrosothiols, Palliative Single-Fraction Whole Liver Radiation Therapy for Diffuse Liver Metastases From Metastatic Merkel Cell Carcinoma, Multi-Institutional Analysis of Stereotactic Body Radiotherapy for Sarcoma Pulmonary Metastases: High Rates of Local Control With Favorable Toxicity, Telomere Dysfunction Activates p53 and Represses HNF4alpha Expression Leading to Impaired Human Hepatocyte Development and Function, Memory-Like Natural Killer Cells for Cancer Immunotherapy, Inadequate and Delayed Characterization of Cutaneous Reactions for FDA Approved Oncologic Drugs From 2011-2020 Leading to Medication Discontinuation, J Am Acad Dermatol 2020 Oct 23; [Epub ahead of print], A Phase II Study of Telisotuzumab Vedotin in Patients With c-Met-Positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-Study S1400K, NCT03574753), Clin Lung Cancer 2020 Oct 14; [Epub ahead of print], Landmark Trials in the Medical Oncology Management of Early Stage Breast Cancer, Evidence Favoring the Efficacy of Convalescent Plasma for COVID-19 Therapy, Biomarkers for Risk Stratification in Patients With Previously Untreated Follicular Lymphoma Receiving Anti-CD20-Based Biological Therapy, Am J Surg Pathol 2020 Oct 30; [Epub ahead of print], Venous Thromboembolism in Multiple Myeloma Is Associated With Increased Mortality, Res Pract Thromb Haemost 2020 Sep 25;4(7):1203-1210, TDP-43 Dysfunction Results in R-Loop Accumulation and DNA Replication Defects, Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction, Beyond Just a Tight Fortress: Contribution of Stroma to Epithelial-Mesenchymal Transition in Pancreatic Cancer, Signal Transduct Target Ther 2020 Oct 30;5(1):249, Disparities in Treatment Patterns and Outcomes Among Younger and Older Adults With Newly Diagnosed Multiple Myeloma: A Population-Based Study, J Geriatr Oncol 2020 Oct 24; [Epub ahead of print], Phase 2 Study of Ruxolitinib and Decitabine in Patients With Myeloproliferative Neoplasm in Accelerated and Blast Phase, Burden of Treatment Among Older Adults With Newly Diagnosed Multiple Myeloma, Clin Lymphoma Myeloma Leuk 2020 Oct 1; [Epub ahead of print], CAR-T Therapy in Solid Organ Transplant Recipients With Treatment Refractory Post Transplant Lymphoproliferative Disorder, Am J Transplant 2020 Oct 22; [Epub ahead of print], Isatuximab as Monotherapy and Combined With Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma, Radiation and Checkpoint Inhibitor Immunotherapy Lead to Long Term Disease Control in a Metastatic RCC Patient With Brain Metastases, A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients With Advanced Melanoma, Non-Small Cell Lung Cancer, or Bladder Cancer, TP53 Abnormalities Correlate With Immune Infiltration and Associate With Response to Flotetuzumab Immunotherapy in AML, Zanubrutinib Monotherapy for Patients With Treatment Naive Chronic Lymphocytic Leukemia and 17p Deletion, Haematologica 2020 Oct 13;Online ahead of print, Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights Into Stromal-Mediated Radioresistance, Diffusion Histology Imaging Combining Diffusion Basis Spectrum Imaging (DBSI) and Machine Learning Improves Detection and Classification of Glioblastoma Pathology, Clin Cancer Res 2020 Oct 15;26(20):5388-5399, Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial, Variability in Cytogenetic Testing for Multiple Myeloma: A Comprehensive Analysis From Across the United States, JCO Oncol Pract 2020 Oct;16(10):e1169-e1180, Treatment Decision-Making in Acute Myeloid Leukemia: A Qualitative Study of Older Adults and Community Oncologists, Leuk Lymphoma 2020 Oct 11:1-12; [Epub ahead of print], Splicing Factor SF3B1 Promotes Endometrial Cancer Progression Via Regulating KSR2 RNA Maturation, Tumor Burden, Inflammation, and Product Attributes Determine Outcomes of Axicabtagene Ciloleucel in Large B-Cell Lymphoma, A Forgotten Friend: CCNU as Palliative Monotherapy in Relapsed Hodgkin Lymphoma, Leuk Lymphoma 2020 Oct 8:1-3; [Epub ahead of print], TGFbetaR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment, Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology, J Natl Compr Canc Netw 2020 Oct 1;18(10):1385-1415, Racial Disparities in the Utilization of Novel Agents for Frontline Treatment of Multiple Myeloma, Clin Lymphoma Myeloma Leuk 2020 Oct;20(10):647-651, Elective Cytoreductive Nephrectomy After Checkpoint Inhibitor Immunotherapy in Patients With Initially Unresectable Metastatic Clear Cell Renal Cell Carcinoma, Clin Genitourin Cancer 2020 Oct;18(5):361-366, Clin Genitourin Cancer 2020 Oct;18(5):341-342, Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial, Clin Cancer Res 2020 Oct 1;26(19):5140-5152, A Phase II Study of Allogeneic GM-CSF-Transfected Pancreatic Tumor Vaccine (GVAX) With Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer, Clin Cancer Res 2020 Oct 1;26(19):5129-5139, Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones, Clonal Hematopoiesis and Risk for Hematologic Malignancy, Older Adult Participation in Cancer Clinical Trials: A Systematic Review of Barriers and Interventions, CA Cancer J Clin 2020 Oct 1; [Epub ahead of print], T Follicular Helper Phenotype Predicts Response to Histone Deacetylase Inhibitors in Relapsed/Refractory Peripheral T-Cell Lymphoma, 10-Day Decitabine With Venetoclax for Newly Diagnosed Intensive Chemotherapy Ineligible, and Relapsed or Refractory Acute Myeloid Leukaemia: A Single-Centre, Phase 2 Trial, IFNL4 and Donor Selection for Matched Unrelated Donor Haematopoietic Stem-Cell Transplantation, Potential Impact of Consolidation Radiation Therapy for Advanced Hodgkin Lymphoma: A Secondary Analysis of SWOG S0816, Phase 1 Study of the MDM2 Antagonist RO6839921 in Patients With Acute Myeloid Leukemia, Invest New Drugs 2020 Oct;38(5):1430-1441, Cooperating, Congenital Neutropenia-Associated Csf3r and Runx1 Mutations Activate Pro-Inflammatory Signaling and Inhibit Myeloid Differentiation of Mouse HSPCs, Initial and Consolidation Therapy for Younger Patients With Mantle Cell Lymphoma, Hematol Oncol Clin North Am 2020 Oct;34(5):861-870, Mechanisms of Resistance to CAR T Cell Therapies, TPL2 Enforces RAS-Induced Inflammatory Signaling and Is Activated by Point Mutations, J Clin Invest 2020 Jun 23; [Epub ahead of print], Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer, Mapping and Characterization of Structural Variation in 17,795 Human Genomes, Nature 2020 May 27; [Epub ahead of print], Potently Cytotoxic Natural Killer Cells Initially Emerge From Erythro-Myeloid Progenitors During Mammalian Development, Exploring the "Minimal" Structure of a Functional ADAMTS13 by Mutagenesis and Small-Angle X-Ray Scattering, Posttranscriptional Modulation of TERC by PAPD5 Inhibition Rescues Hematopoietic Development in Dyskeratosis Congenita, Mutation Clearance After Transplantation for Myelodysplastic Syndrome, N Engl J Med 2018 Sep 13;379(11):1028-1041, An "Off-The-Shelf" Fratricide-Resistant CAR-T for the Treatment of T Cell Hematologic Malignancies, Board Review: Clinical Research Methodology, Head, Neck, Thyroid and CNS Cancer, Board Review: Genetics / Tumor Biology, Gynecologic Cancer. The division has recruited over 80 faculty and has a staff that now exceeds 400. Mutation Clearance and Complete Radiologic Resolution of Immunotherapy Relapsed Metastatic Melanoma After Treatment With Nivolumab and Olaparib in a Patient With Homologous Recombinant Deficiency: Any Role for PARP Inhibitors and Checkpoint Blockade? In 1997, Dr. Ihde moved to the Moffit Cancer Center in Tampa, Florida, and Dr. DiPersio was appointed the interim Chief of the Division of Medical Oncology. Our program has performed over 5,000 bone marrow and stem cell transplants since its inception, making it one of the top five programs in the country. Korsmeyer, Tim Ley and John Atkinson joined together to establish and build these programs in 1994. WU Record 1/17/20, Washington University has received a $3.7 million grant from the National Institutes of Health to support an open-source database aimed at boosting personalized approaches to cancer treatment. William Peck and Lawrence Shapiro), the Division of Oncology has grown to over 70 faculty that focus in diverse research areas of basic and translational/clinical cancer biology and cancer care. In 2008, Dr. Picus assumed management of the program, assisted by Hematology Division Chief, Dr. Evan Sadler. Specialties: Hematology, Hematology Oncology. Board-certified in medical oncology and hematology, Dr. Zandberg received his medical degree from Jefferson Medical College in Philadelphia. A phase 1 clinical trial to test the safety of FAK inhibitors in patients with advanced pancreatic cancer is underway. Members of the Division of Oncology are leaders in national and international efforts (through NCI and NHRGI-funded projects) to fully decode mutations associated with initiation and progression of cancers, both hematologic and solid tumor. The Hematology-Oncology Fellowship Training Program at the University of Washington is designed to develop academic physicians who are competent in clinical hematology/oncology and research. Education and Fellowship Training . Washington University oncologists at the Siteman Cancer Center devote their efforts to preventing, diagnosing and treating cancer. Contact. Genome sequencing and protein analysis of the tumors will be performed to seek clues to how some of them develop drug resistance. They established two separate divisions that emerged from the need to expand the clinical activities that were, up until that time, a part of the division of Hematology-Oncology. Jeff Ward and Chris Miller are members of a global consortium that has identified features of tumor neoantigens that trigger T cells to attack the cancer and leave healthy tissue untouched. Ira Hall will serve as co-lead principal investigator of the new program. 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