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However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Osteopenia Prescribing Information and This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. But weight gain may occur with other medications you take or other health conditions you have. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). You might be interested in seeing how Prolia and the drug Boniva compare. Now i'm wondering if i shouldn't take K2. What should I know about Prolia vs. Xgeva? With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. If you have serious side effects from Prolia, call your doctor right away. If you have low blood calcium, it may get worse during treatment. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. * Approximation only. eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. Prolia comes with a warning about a low level of calcium in the blood. Yoga is an excellent way to manage symptoms of osteoporosis. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Here are some frequently asked questions about the drugs side effects and their answers. Patients in the study may take other drugs besides Prolia and Calcium. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. People need calcium for bone health and other functions. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. What are the possible side effects of Prolia? If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. They can also suggest ways to relieve this side effect. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines They can also tell you about other treatment options available for osteoporosis and bone loss prevention. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. It is important not to miss your dose. With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. (Vitamin D helps your body absorb calcium.) Over time, Prolia can reduce bone loss and make your bones stronger. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. The drug could cause your calcium level to drop too low. What should I know about Prolia vs. Reclast? The conditions and factors to consider include: Upcoming dental procedures. Your low blood calcium must be treated before you receive Prolia. So be sure to tell your doctor about all your health conditions before taking Prolia. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. WebMost people can get adequate calcium through their diet if they make an effort. Women Your risk of bone fractures can increase when you stop, skip or delay using Prolia. In fact, bone breakdown is higher in the first several months after you stop Prolia. Prolia isnt known to cause any harmful interactions with alcohol. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. Low blood calcium level. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. Bring someone with you to your appointment if doing so will help you feel more comfortable. And if you have osteoporosis, falling could increase your risk of fractures. Learn strategies you can use today. If you are pregnant, you should not take Prolia. Prolia solution is available in one strength: 60 milligrams per milliliter (mg/mL). Prolia contains the active ingredient denosumab. Learn more about your health after menopause. You will receive your Prolia injection from your healthcare provider at a their office or clinic. If you have low calcium levels, you should not take Prolia. If you develop hypocalcemia, your doctor will typically have you stop using Prolia. Drug class: Miscellaneous bone resorption inhibitors. Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. (Chlorhexidine helps kill germs in your mouth.). For Xgeva, talk to your pediatrician regarding the use of this medicine in children. But theyre each effective in treating osteoporosis and preventing bone loss. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Since different people Hair loss wasnt reported as a side effect during clinical trials of Prolia. Tell them if you have any scheduled dental work coming up. Tell your doctor if you become pregnant. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. Using Prolia for Bone Loss in People With Breast Cancer A special MedGuide will be given to you before each treatment. It is often used in osteoporosis. These effects are called interactions. How long will I need to keep taking Prolia? Below are answers to some commonly asked questions about Prolia. You should not receive Prolia if you are allergic to denosumab, or if you Serious side effects from Prolia can occur, but they arent common. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. So, your bones become weak and brittle. In addition, you should use effective birth control while youre taking Prolia. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Calcium Supplements: Should You Take Them? - Johns Hopkins Every 6 months youll get another dose of Prolia. you Instead, it belongs to a different group of medications called biologics. Prolia Side Effects: Common, Mild, and Serious - Healthline But if you think youre having a medical emergency, call 911 or your local emergency number. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. What's the difference between Prolia and Reclast? Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Throw away a prefilled syringe after one use, even if there is still medicine left inside. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Youll receive Prolia doses from a healthcare professional. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Stopping Prolia doesnt cause withdrawal symptoms. And in my mind, that's no different than scheduling a visit to the dentist twice a year. But doing so can cause more bone breakdown and increase your risk for bone fractures. For a basic overview of Prolia, including details about its uses, see this article. This is because the drug may be harmful to a growing fetus. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. What should I know about Prolia vs. Zometa? Prolia is injected under the skin. (BMD is a measurement of the amount of minerals such as calcium in your bones.) Osteoporosis is a condition that causes your bones to become thin and weak. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. * Sex and gender exist on spectrums. The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. Prolia can also cause bones to not form correctly and reduced growth in a fetus. Our website services, content, and products are for informational purposes only. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. Can diet help improve depression symptoms? WebDrug interactions are reported among people who take Prolia and Calcium. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Prolia also carries a warning about hypocalcemia, which is a low level of For more information about how Prolia and Zometa compare with each other, see this article. We comply with the HONcode standard for trustworthy health information. High cholesterol levels can be a side effect of Prolia. (2021). Prolia may be used off-label for RA, if you have a high risk for bone fractures. Learn more details about some of the side effects that Prolia may cause. Others may continue for as long as you take the drug, but they can be easily managed. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. If youre concerned about weight gain with Prolia, talk with your doctor. Breastfeeding. They can suggest ways to help relieve these side effects. Learn how to increase or maintain bone density here. They have some similar uses and side effects, but they also have some differences. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. But Zometa contains the active drug zoledronic acid. But, in some cases, alcohol can affect your balance and increase your risk for falls. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture. If youd like a detailed comparison of Prolia versus Boniva, view this article. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) Prolia can cause many serious side effects. You should also take calcium and vitamin D supplements while being Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. If youve already gone through menopause, your risk for bone loss is increased. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Calcium Supplements You might like to know how Prolia and the drug Evenity compare. supplements Tell your doctor if you become pregnant. Talk with them about your health and any concerns you have about Prolia and its effects. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. Fracture in the spine after stopping Prolia treatment. All rights reserved. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. See additional information. Check with your doctor if you have more questions about these drugs. Q: Does AlgaePlus Increase Bone Mass? Our phase IV clinical studies alone cannot establish cause-effect relationship. As with most drugs, Prolia can cause an allergic reaction in some people. This is not a complete list of warnings for Prolia. They may also have you see your dentist. Thyroid or parathyroid surgery. Do not use denosumab if you are pregnant. And ask your doctor about which drug is right for your condition. Youll receive 60 mg/mL of Prolia once every 6 months. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. Prolia improves bone mass and increases bone mineral density. You may report side effects to FDA at 1-800-FDA-1088. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Vitamin D The body needs vitamin D to absorb calcium. It does the same thing that. You are encouraged to report negative side effects of prescription drugs to the FDA. You may wonder how Prolia compares to the medication Zometa. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. The Prolia is making my leg bones and jaw bones hurt. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. Continue reading, Prolia (denosumab) does increase bone density. The fractures may require surgeries, take several months to heal, or both. You may be interested in learning how Prolia compares to the medication Fosamax. But certain choices and habits accelerate the process. These can include tingling or numbness in the hands, feet, and face. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. The drug stays in your system and continues to slow bone breakdown over this period of time. Follow your doctor's instructions. Prolia injections administered by a healthcare professional. And some of these side effects are more common with certain uses of Prolia. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. They can treat the infection as needed. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. To learn more about these two drugs, check out this drug article. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. If you have a male* sexual partner, they should use birth control during this time as well. The use of the eHealthMe site and its content is at your own risk. Find out why people need calcium, which foods provide it, and what happens if they consume. They can help you decide whether the possible benefits for your condition outweigh your risks for serious side effects. If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. have happened in people who take Prolia. Osteoporosis medications and medication-related osteonecrosis of the jaw. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. that's no different than scheduling a visit to the dentist twice a year. Heres a sample meal plan thats packed with nutritious foods just for. This makes your bones weak and increases your risk for bone fractures or breaks. If youre concerned about tingling while using Prolia, talk with your doctor. Youll receive Prolia doses from a healthcare professional. Be sure to read this information carefully each time. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. Some examples of these treatments include: Talk with your doctor about other drugs you may need to take with Prolia. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. And some of these side effects are more common with certain uses of Prolia. For more information about how these medications compare with each other, ask your doctor. Do not treat yourself. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. You can use the study as a second opinion to make health care decisions. Whats the Connection Between Estrogen and Osteoporosis? If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. Based on your dental history, your doctor can discuss with you the risks of using Prolia. Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. Its given to adults who are at high risk for bone fractures. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Last medically reviewed on November 29, 2022. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. If youre pregnant or breastfeeding, or considering either, talk with your doctor. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures Youll likely have questions about your condition and treatment choices. These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. Be sure to talk with your doctor about your health history before you take Prolia. These are not all the possible side effects of Prolia. Theyll do this with certain tests, such as a bone scan or ultrasound. Denosumab Injection: MedlinePlus Drug Information You may also want to do some research on your own. Below, we answer some common questions about taking Prolia. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. For women with osteoporosis after menopause at high risk for fracture. Common The list below may not include all possible serious side effects of the drug. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. Special care may be needed. Copyright 2023 Elsevier Inc. All Rights Reserved. They can explain the risks and benefits of this drug. These are serious. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. Talk with your doctor before starting Prolia treatment. Prolia may cause serious side effects. Take only the amount of calcium and vitamin D that your doctor has prescribed. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. It can have some side effects, but these may depend on who uses it. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. But its not clear whether this side effect occurred in clinical studies. you can take. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Its important to practice good oral hygiene during Prolia treatment. Prolia is an injection prescribed for certain adults with osteoporosis, which Prolia: Side Effects, Alternatives, How It's Administered, We avoid using tertiary references. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. A healthcare provider will give you this injection in a hospital or clinic. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. Some reports may have incomplete information. The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. (Biologic medications are made from living organisms.). (2022). Do not stop, skip or delay taking Prolia without first talking with your doctor. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. Your doctor can help you decide which drug is better for your needs. Learn more about some of the side effects Prolia may cause. You But Prolia is given once every 6 months by a healthcare professional. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. It comes as a liquid solution thats given as an injection. WebYou should take calcium and vitamin D as your doctor tells you to while you receive The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). (Biosimilars are like generic drugs. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. What are some frequently asked questions about Prolia? You may need to have a dental exam before you begin treatment with Prolia. These include osteonecrosis of the jawbone. Xgeva is also used to treat giant cell tumor of the bone. This aids in keeping your calcium level within the recommended range. Continue reading. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number.