(2) Except as otherwise provided in this subchapter, the MARINE POLLUTANT mark shall be placed in association with the hazard warning labels required by subpart E of this part or, in the absence of any labels, in association with the marked proper shipping name. Tremor. WebLINDANE ICSC: 0053 IMPORTANT DATA PHYSICAL STATE; APPEARANCE: ODOURLESS, WHITE CRYSTALLINE POWDER CHEMICAL DANGERS: On contact with hot surfaces or flames this substance decomposes forming toxic and corrosive fumes including phosgene and hydrogen chloride. 0000001244 00000 n
The substance may cause long-term effects in the aquatic environment. WebInternational initiatives on Lindane include the Protocol on Persistent Organic Pollutants of the Convention on Long Range Transboundary Air Pollution; the Rotterdam Convention; the OSPAR Commission for the Protection of the Marine Environment of the Northeast Atlantic, the Great Six cases of congenital anomaly were also describedfive for infants "possibly" exposed to lindane in utero and one paternal exposurebut no characteristic pattern of effect was noted. WebLindane Can Be Toxic to Humans Lindane, also known as g-hexachlorocyclohexane (g-HCH), is commonly used in shampoos and other topical treatments for head lice and (e) MARINE POLLUTANT mark. However, lindane medications remain available in Canada for public health purposes as non-prescription therapies. Lindane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. [1] Adverse hematologic effects have also been reported with chronic occupational exposures and excessive dermal applications; however, a direct cause and effect has not been established. [25] In 2002, the EPA concluded that lindane agricultural products were eligible for re-registration given industry compliance with certain data and labeling requirements to mitigate occupational risks to workers. Perspectives of lindane (-hexachlorocyclohexane) Diarrhoea. Further see Ingestion. Studies of the carcinogenic effects of lindane have been inconclusive and often limited by study design; however, no major carcinogenic effects have been noted in human trials to date. The authors concluded that "The California experience suggests elimination of pharmaceutical lindane produced environmental benefits, was associated with a reduction in reported unintentional exposures and did not adversely affect head lice and scabies treatment. WebIn the case of marine pollutants also meeting the criteria for inclusion in another hazard class, all provisions of this subchapter relevant to any additional hazards continue to The direct causes of death for the other cases were attributed to reasons other than lindane. (Note: These events represent the most common reported to the FDA and do not represent the most common events associated with the use of lindane lotion and lindane shampoo overall). Nausea. Vlkov and Hofman demonstrated that soil properties affect the bioavailability of persistent organic pollutants such as lindane, DDT, phenanthrene and [15] Central nervous system stimulation ranging from dizziness to seizures, has also been reported; however, serious effects, like seizures, have almost always resulted from oral ingestion or misuse of medication (e.g., repeated treatments or prolonged applications). eCFR :: 49 CFR 172.322 -- Marine pollutants. WHITE CRYSTALLINE POWDER. Lindane Fish, marine mammals and birds in the region are exposed to environmental pollutants, increasing the stress of the marine ecosystem. pollution Lindane (-BHC) is an organochlorine insecticide that is classified as a persistent organic pollutant (POP), and serious health problems can arise after 104 0 obj
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Find out how LUMITOS supports you with online marketing. However, Morton Grove presented new facts supporting its case for jurisdiction in Illinois and the Court held that Morton Grove's "Second Amended Complaint would provide specific jurisdiction over the Center and Weil." Do not eat, drink, or smoke during work. Carefully collect remainder. 0000006190 00000 n
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To use all functions of this page, please activate cookies in your browser. The mark may be displayed in black lettering on a square-on-point configuration having the same outside dimensions as a placard. It has an oral LD50 of 88 mg/kg in rats and a dermal LD50 of 1000 mg/kg. A marking in conformance with the requirements of this paragraph in effect on December 31, 2014, may continue to be used until December 31, 2016. Hepatic cytochrome P-450 oxygenase system. This requirement may be met by the marking displayed on a freight container or portable tank loaded on a motor vehicle or rail car. Effects of long-term or repeated exposure
Sweep spilled substance into sealable non-metallic containers. [7], In 1995, lindane medications were designated second-line and are now reserved for patients who are unable to tolerate or have failed first-line treatmentsa growing problem in the U.S. and elsewhere due to increased rates of resistance. [4] There is a bill in the New York State Assembly and Senate to ban its use in head lice products and limit its use on scabies, which had not passed as of September 2007. Lindane (Gamma-Hexachlorocyclohexane) - US EPA This is the third severe geomagnetic storm (G4) since Solar Cycle 25 began in 2019. [7][8][9] The U.S. Centers for Disease Control and Prevention also includes lindane medications in their Sexually Transmitted Disease Treatment Guidelines as viable treatment alternatives for the management of scabies and pubic lice, consistent with the approved prescription labeling for these products. Hexachlorocyclohexane This produces toxic and corrosive fumes including hydrogen chloride and trichlorobenzenes (see ICSCs 0344, 1049 and 1222). (1) On single packagings or combination packagings where each single package or each inner packaging of combination packagings has: (i) A net quantity of 5 L (1.3 gallons) or less for liquids; or, (ii) A net mass of 5 kg (11 pounds) or less for solids. [1] In 2003, the EPA reported on the results of large-scale water contaminant testing of 16,000 water systems serving 100 million people across the U.S. and found that none contained lindane levels above the maximum contaminant level standard considered safe. [15], The current FDA-approved product labeling emphasizes that lindane medications are contraindicated for use in premature infants and individuals with known uncontrolled seizure disorders and should be used with caution in infants, children, the elderly, and individuals with other skin conditions (e.g., atopic dermatitis, psoriasis) and in those who weigh less than 110 lbs (50 kg) as they may be at risk of serious neurotoxicity. This substance does enter the environment under normal use. "[14], The most common side effects associated with topical use of lindane medications are nonserious reactions of the skin, including burning, itching, dryness and rash. ILO and WHO 2021. Lindane (Ref: OMS 17) - University of Hertfordshire (June 8, 2007 order). Column 1 is labeled S.M.P. for Severe Marine Pollutants and Column 2 is Toxicity of phenanthrene and lindane mixtures to marine The substance is very toxic to aquatic organisms. 0000001686 00000 n
Lindane, also known as gamma-hexachlorocyclohexane (-HCH) and benzene hexachloride (BHC), is an organochlorine insecticide that has been used in agriculture and in pharmaceutical products for the treatment of headlice and scabies. Samples of intestinal tissues were prepared in both control The Persistent Organic Pollutants Review Committee of the Stockholm Convention on Persistent Organic Pollutants considers the use of lindane in agriculture as largely redundant, with other, less toxic and less persistent pesticides. People who are occupationally exposed to it are advised to avoid its contact with eyes, skin and via inhalation. [32][33] In the U.S., petitions to ban the use of pharmaceutical lindane have been rejected by the FDA and determined to be without merit by experts working with this regulatory agency. Refer immediately for medical attention. 0000047710 00000 n
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United Nations Environment Programme - POPs [20] The majority of studies of the general population have also shown no association between serum or breast tissue levels of lindane and breast cancer. (4) On a package of limited quantity material marked in accordance with 172.315 of this part. [1] Vomiting and nausea are usual symptoms associated with oral ingestions of lindane but serious neurologic effects can occur, albeit less frequently. WebLindane is considered to be highly toxic to aquatic organisms, and moderately toxic to birds and mammals. (3) Except for transportation by vessel, on a bulk packaging, freight container or transport vehicle that bears a label or placard specified in subparts E or F of this part. Headache. CFR Title 49. Transportation 49 CFR 172.101, App. B Lindane is categorized as a persistent organic pollutant, and its concentrated form persists in the aquatic environment. WebThe table located at Appendix B to 172.101, List of Marine Pollutants, contains two columns. It is highly toxic to fish and honeybees and moderately toxic to most Dizziness. During this time, the vast majority of lindane usemore than 99%has been for agricultural purposes and much of the safety and environmental concerns have related to this application. 2-ethyl-hexyl-4-trimethoxycinnamate (Octinoxate, Uvinul MC80) Glyceril octanoate dimethoxylcinnamate. [15] (see also Pharmaceutical Uses) Lindane has not been shown to alter immunocompetence in humans and is not considered to be genotoxic. If appropriate, moisten first to prevent dusting. WebThis Lindane Reregistration Eligibility Decision (RED) Document replaces the earlier National Marine Fisheries Service No Observed Adverse Effect Level National Pollutant Discharge Elimination System EPA Office of Pesticide Programs Population Adjusted Dose Pesticide Analytical Method Public Document PIC [30][31]The US FDA continues to maintain that lindane medications have necessary health benefits that outweigh potential risks and should remain available for patients with head lice, scabies and pubic lice (crabs) who have few treatment alternatives. [6] Most exposure of the general population to lindane results from agricultural uses and the intake of contaminated foods, such as produce, meats and milk. This substance is carcinogenic to humans. This mark may be displayed in black lettering on a white square-on-point configuration having the same outside dimensions as a placard. trailer
Lindane, Hexachlorocyclohexane (Technical Grade), A medication guide, written in plain English, was also developed and is now required by law to be dispensed with every lindane prescription dispensed in the U.S. to better educate patients and caregivers on safe application technique. Aurora is best viewed in areas without light pollution and no cloud cover. The substance may cause effects on the central nervous system. Not combustible. Air pollution on the Front Range has gotten worse, EPA Gives off irritating or toxic fumes (or gases) in a fire. The most common side effects are nonserious reactions of the skin (e.g., burning, itching, dryness and rash). (see also Regulatory Status). Read what you need to know about our industry portal chemeurope.com. Chemical dangers
Fresh air, rest. This article is based in part on the public domain US government document at FDA.gov. Lindane Severe Marine Pollutants - ReadyGo Then store and dispose of according to local regulations. A wide range of pollutionfrom plastic pollution to light pollutionaffects marine ecosystems. (d) The MARINE POLLUTANT mark is not required -. (ii) At least 250 mm (9.8 inches) for marks applied to all other bulk packages. WebThe concentration addition model was applied to determine whether toxicity of two compounds, phenanthrene (polycyclic aromatic hydrocarbon) and lindane If the size of the package so requires, the dimensions/line thickness may be reduced, provided the marking remains clearly visible. WebLindane, a lipophilic pollutant, may be toxic to organisms. [1][21] Similarly, no increased cancer risk was noted in a large epidemiologic study of lindane medications involving a 143,594-patient database with up to 21 years of follow up, which concluded that There is still no persuasive evidence from studies of humans that lindane, as ordinarily used clinically, is carcinogenic in humans. [22] Lindane (Persistant Organic Pollutant) in the EU, Best Practices of De-Contamination Exchanged. WebLindane has been listed as a pollutant of concern to EPA's Great Waters Program due to its persistence in the environment, potential to bioaccumulate, and toxicity to humans Do not transport with food and feedstuffs.