Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age. Osteoporos.Int. Meunier PJ, Slosman DO, Delmas PD, et al. Protelos European Public Assessment Report, Scientific Discussion. (. A meta-analysis of randomized controlled trials. Medi-Physics, Inc., Amersham Healthcare, Arlington Heights, IL, 1998. https://www.cancerpaintherapy.com/METATECHPAGE.htm. In the human body, approximately 99 percent of Sr is located in the bones. J.Fam.Pract. (2). Olson, B. L., McDonald, J. L., Jr., and Stookey, G. K. The effect of strontium and fluoride upon in vitro plaque and rat caries. Ann Intern Med 2007;146:580-90. 1992;19(10):737-740. View abstract. View abstract. Bone. I did find some information on the Mayo Clinic website on osteoporosis. Strontium 89 in the treatment of pain due to diffuse osseous metastases: a university hospital experience. View abstract. View abstract. Do not take it within 2 hours of ingesting calcium so I take it at bedtime. How Well are You Living With Ankylosing Spondylitis? J Clin.Dent. Doctors arent sure exactly how it works, but it seems to help the body make more bone and keep the bone you have from breaking down. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. This supplement supports healthy osteoblast differentiation osteoblast collagen formation and balanced osteoclast activity; all of these activities help you maintain bone tensile strength. Effectiveness of desensitizing agents. Injecting myself daily. Sr supplements are controversial and should be considered very carefully. View abstract. People with prostate cancer sometimes have the cancer metastasize and spread to their bones. Nonvertebral fracture benefit from oral ibandronate administered daily or with a unique drug-free interval: Results from a pivotal phase III study in postmenopausal osteoporosis (PMO). Eur.J.Endocrinol. 1978;57(9-10):903. are clickable links to medically peer-reviewed studies. Perit Dial Int 1998;18:410-4. View abstract. Esomeprazole (Nexium) is not the same medication as esomeprazole strontium, although both are used to treat similar stomach conditions. Select a condition to view a list of vitamins. According to Wikipedia, Strontianite(SrCO3) is an important raw material for the extraction ofstrontium. A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis. View abstract. There were, however, significant increases in both heart attacks and blood clots (including pulmonary embolism) in patients taking strontium ranelate compared to those who were not. Can Med Assoc J 1981;125:703-12.. View abstract. How can Sr be used? Strontium Boost is an all-natural organic supplement that supports bone health in people of every age. A., Korotkova, T. A., Toroptsova, N. V., Smirnov, A. V., Demin, N. V., Rodionova, S. S., Buklemeshev, IuV, and Shumskii, A. View abstract. There are many safe food sources and if you are not able to reach your daily calcium requirements through your diet, you may need a supplement. All rights reserved. J Clin Endocrinol Metab 2002;87:2060-6.. View abstract. Osteoporos.Int. Many consumers are being lured by the advertised benefits of strontium for bone health. Reginster, J. Y., Lecart, M. P., Deroisy, R., and Lousberg, C. Strontium ranelate: a new paradigm in the treatment of osteoporosis. Is reclast a safe treatment for osteoporosis I have not done anything so far except strontium citrate? 2008;67(12):1736-1738. Verberckmoes SC, De Broe ME, D'Haese PC. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. Medina, J. M., Thomas, A., and Denegar, C. R. Knee osteoarthritis: should your patient opt for hyaluronic acid injection? View abstract. Liberman, U. Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. Bruyere, O., Roux, C., Detilleux, J., Slosman, D. O., Spector, T. D., Fardellone, P., Brixen, K., Devogelaer, J. P., Diaz-Curiel, M., Albanese, C., Kaufman, J. M., Pors-Nielsen, S., and Reginster, J. Y. Its also referred to as being a soft metal like lead. 7-27-1965;162(989):458-472. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial. I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. Chesnut, C. H., III, Silverman, S., Andriano, K., Genant, H., Gimona, A., Harris, S., Kiel, D., LeBoff, M., Maricic, M., Miller, P., Moniz, C., Peacock, M., Richardson, P., Watts, N., and Baylink, D. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. Cochrane Database Syst Rev 2005;(2):CD002946. About 99% of the strontium in the human body is concentrated in the bones. J.Periodontol. Am on third brand of Strontium Citrate and doing better than on the first two. Bruyre O, Reginster JY, Bellamy N, et al. Low . 1970;41(12):702-703. [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. A 2016 systematic review published in European Urology took a look at several radiopharmaceuticals including Sr-89 for reducing the malignant bone pain from prostate cancer. Am J Med 1993;95:69S-74S. J Periodontol. However, I dont advocate using these supplements without first reviewing the precautions listed below and talking with your health care provider. N.Engl.J.Med. To avoid this interaction, take strontium at least 2 hours before or after taking tetracyclines. ", Human Nutrition, Food & Animal Sciences, University of Hawaii at Manoa: "European strontium drug spurs supplement sales in U.S.", National Osteoporosis Society: Drug treatments for osteoporosis: strontium ranelate (Protelos).. The possible risks of strontium warrant more long-term independent studies. View abstract. View abstract. Meanwhile, strontium citrate features a 31% elemental strontium and only 69% citrate. Boron is an element. Clin Nucl Med 2004;29:81-5. I now take 680 mg strontium citrate without side effects and the fractures have stopped. 2007;357:nihpa40967. Dermatology 2000;200(3):244-246. 2011;165(3):469-476. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Br.J.Clin.Pharmacol. Strontium results in an overestimation (up to 50%) of the increase in bone density using DXA methods.[3]. Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss. Good luck to all of you. J Bone Miner Res 1999;14:1789-95. View abstract. 1998-2023 Mayo Foundation for Medical Education and Research. Arch.Intern.Med. Naess, I. J.Dent.Res. Unfortunately, a lot of toothpastes that contain Sr may contain a lot of other questionable ingredients, so I recommend sticking with a natural toothpaste or making your own at home such as myHomemade Probiotic Toothpaste. 1990;1(1):19-23. (Accessed 13 March 2004). Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. View abstract. Malaise, O., Bruyere, O., and Reginster, J. Y. Strontium ranelate normalizes bone mineral density in osteopenic patients. 3-23-1998;158(6):585-593. 2010;21(2):49-55. Boron has been consumed for menstrual cramps and boric acid has been used vaginally for yeast infections, but evidence is limited. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Kidney Int 1999;56:1886-92. Eur.J.Nucl.Med. View abstract. Receive updates and information about Bone Health, Our Events, and Specialty Programs each month. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. 2006;(2):CD005321. View abstract. Its also not for people who: National Osteoporosis Foundation Clinical Updates: "Over-the-Counter Products & Osteoporosis: Case Discussions. Calcium citrate is another of the more common calcium types used in calcium supplements. J.Clin.Periodontol. Even though its not considered a nutrient, its known that the human body can absorb strontium and utilize it as it would calcium. What does this alkaline earth metal look like in nature? Calcif Tissue Int 2000;67:122-7. I found that Strontium is eliminated by the kidneys and can build up in people with poor kidney function. View abstract. Causes, symptoms, risk factors, and treatment. A., Weiss, S. R., Broll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J., Downs, R. W., Jr., Dequeker, J., and Favus, M. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. Minkoff S, Axelrod S. Efficacy of strontium chloride in dental hypersensitivity. View abstract. Arch Intern Med 2003;163:1514-22. Adami, S. Protelos: nonvertebral and hip antifracture efficacy in postmenopausal osteoporosis. N.Engl.J.Med. Kidney Int 2003;64:534-43. . "Hello @bonelady. J.Clin.Endocrinol.Metab 2010;95(3):1174-1181. View abstract. 1992;19(3):197-201. J.Periodontol. According to the Michigan Health website: Compared with children with fewer cavities, enamel samples from children with high numbers of caries have been found to contain significantly less strontium. They won't do any studies but the END OF FRACTURES SAYS IT ALL! View abstract. Sr can be found in Group 2 of the periodic table. Strontium, which is a trace element found in seawater and soil, has a chemical similarity to calcium and can replace calcium in the bone. Benefit: Bone & Joint Health. View abstract. View abstract. View abstract. Its been compared to calcium in its bone-boosting abilities. View abstract. They. JAMA 1995;274:420-4. 2005;16(10):1291-1298. Some antacids include calcium carbonate (Tums, others), dihydroxyaluminum sodium carbonate (Rolaids, others), magaldrate (Riopan), aluminum hydroxide (Amphojel), aluminum hydroxide/magnesium hydroxide combinations (Maalox, Mylanta), and others. A 2007 study only involved six participants, but the researchers found thatregular toothbrushing with a strontium-supplemented toothpaste has been found to increase the strontium content in the exposed enamel, which can be an advantage in the prevention of cariogenesis. (15) What is cariogenesis? Quintessence.Int. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. [No authors listed]. Some male hormones include testosterone, nandrolone, oxandrolone, and oxymetholone. Pearce, N. X., Addy, M., and Newcombe, R. G. Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. Reduce bone loss and build stronger muscles. View abstract. Strontium can attach to some antibiotics called tetracyclines in the stomach. If you check your calcium supplement and the supplement facts include calcium carbonate, calcium citrate, or some other name, it is simply ground rocks. Tofu, firm, made with calcium sulfate, cup 253 mg per serving. A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. Clin.Prev.Dent. Hwang, J. S., Chen, J. F., Yang, T. S., Wu, D. J., Tsai, K. S., Ho, C., Wu, C. H., Su, S. L., Wang, C. J., and Tu, S. T. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis. View abstract. Selective Estrogen Receptor Modulators (SERMs), Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Bone Mineral Density Test: What to Expect, Newer Osteoporosis Treatments Build Stronger Bones, Breakfasts for Strong Bones: 12 Foods to Boost Bone Health, Cant move very much, either for a short time, such as after surgery, or for the long term, such as because of a disability. 2008;19(4):503-510. Apostolidis N, Paradellis T, Karydas A, et al. Type: Natural Calcium & Magnesium Supplement. However, there has also been concern over strontium ranelates effects on heart health. In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Here with us today, we have two experts. I will be contacting my urologist who I just began working with to let her know about Strontium. Methods: Custom-made MDO devices were placed on 20 New Zealand White rabbits. Connect with thousands of patients and caregivers for support and answers. J.Clin.Periodontol. Available at: www.emea.eu.int/humandocs/Humans/EPAR/protelos/protelos.htm. Maheu E, Mazieres B, Valat JP, et al. (12). View abstract. View abstract. Accessed May 1, 2018. 5-10-2001;344(19):1434-1441. Hello @bonelady. [4] Simpson, Lani. The effect of fluoride and strontium application on dentin: in vivo and in vitro studies. Bellamy, N., Campbell, J., Robinson, V., Gee, T., Bourne, R., and Wells, G. Viscosupplementation for the treatment of osteoarthritis of the knee. According to Cancer Research UK, If there are cancer cells in more than one area of bone, radioactive strontium can work well to treat those areas and reduce pain. (11). Phone & Address: 1-800-820-0184; support@algaecal.com. You can buy different forms of it, such as strontium citrate, in supplements at supermarkets and health food stores. (18), Sr is said to be the 15th most abundant element on Earth and its common to find it in nature. Barenholdt, O., Kolthoff, N., and Nielsen, S. P. Effect of long-term treatment with strontium ranelate on bone strontium content. The most common supplement form is strontium citrate. O'Donnell S, Cranney A, Wells GA, et al. US Department of Health and Human Services, Public Health Service. View abstract. It is an alkaline earth metalmost similar to barium and calcium. Osteoporosis Int. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. Can and should treatments such as these be used in conjunction with strontium citrate, about which I know nothing by the way? View abstract. Membership to ConsumerLab.com is available online and provides immediate access to reviews of more than 1,000 products from over 400 brands. As a service to our readers, American Bone Health provides access to our library of archived content. Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. Strontium ranelate is available as a prescription medication in Europe and Australia, but it has not been approved by the FDA in the United Sates. Strontium may also influence other essential functions, including calcium absorption, bone formation & breakdown, and it restores alkaline pH to improve the health of skin, hair, and nails). D'Haese PC, Couttenye MM, Lamberts LV, et al. All Rights Reserved. J.Fam.Pract. This information may not fit your specific health circumstances. More Information View abstract. I have been treated with bisphosphanates, forteo, prolia and I had 11 non-traumatic spontaneous vertebral compression fractures during treatment. Results 12 weeks following cessation of 8 weeks' supervised use. Physio Flex Pro - Editor's Choice. View abstract. Ozgur S, Sumer H, Kocoglu G. Rickets and soil strontium. 2015 Feb;74(2):422-9. doi: 10.1136/annrheumdis-2013-203989. Kanapka, J. Bianchi ML, Ardissino GL, Schmitt CP, et al. B., Gamble, G. D., and Reid, I. R. Effect of osteoporosis treatment on mortality: a meta-analysis. You may be surprised, but strontium chloride hexahydrate is added to toothpaste to reduce the pain associated with sensitive teeth. 9-1-2005;30(17 Suppl):S84-S91. View abstract. Zhai, H., Hannon, W., Hahn, G. S., Harper, R. A., Pelosi, A., and Maibach, H. I. Strontium nitrate decreased histamine-induced itch magnitude and duration in man. I am actively and urgently in the process of deciding which osteoporosis treatment I want to "pitch" to my doctors. View abstract. J Can Dent Assoc 2003;69:221-6. Reginster JY, Kaufman JM, Goemaere S, et al. View abstract. Strontium has a long list of undesirable side-effects, commonly ranging from nausea to skin irritation, and less often (fortunately), blood clots and fainting. Lancet 12-7-1996;348(9041):1535-1541. PROOF Study Group. A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. 2006;55(8):669-675. If youre not into chemistry, then those scientific facts probably dont mean that much to you. It is given as an injection every month at your doctor's office and is limited to one year of treatment. You may not realize it, but its possible that you have used, or are currently using, a toothpaste the contains strontium. (24, 25). El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? Fluoride helps protect your teeth from the acid that is released when this happens. J BoneMiner Res 2002;17 [Suppl 1](S35). View abstract. Incorporation and distribution of strontium in bone. Gillam, D. G., Newman, H. N., Bulman, J. S., and Davies, E. H. Dentifrice abrasivity and cervical dentinal hypersensitivity. Proc.R.Soc.Lond B Biol.Sci. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. J.Dent.Res. Strontium ranelate has risks though. [1] PRAC recommends suspending use of Protelos/Osseor. 2014. Cochrane.Database.Syst.Rev. Springer, 2019. It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. It has shown only a modest effect in preventing recurrent vertebral fractures. View abstract. Description Pure Encapsulations' Strontium capsules provide one of the many trace minerals essential to bone health. One scientific review published in 2014 by a doctor with admitted ties to pharmaceutical makers concludes, The increased risk for cardiac events with strontium ranelate has been detected in randomized clinical trials but not in real-life observational studies. (9), Ultimately, the European Union now only endorses the use of strontium ranelate in severe cases of osteoporosis with high fracture risk.